Of pharmaceutics, jaipur college of pharmacy, sitapura, jaipur raj. Pdf formulation and evaluation of floating microsphere. The drug to polymer ratio was used to prepare the different formulation. Optimization of methods for the preparation of famotidine. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The purpose of this study is to formulation and invitro evaluation of mucoadhesive floating microspheres of repaglinide using solvent evaporation method. Research paper preparation and characterization of. Preparation of ritonavir floating microspheres 5 the floating microspheres containing ritonavir were prepared by orifice ionic gelation technique. The microspheres were analyzed for drug entrapment, bulk density, angle of repose, particle size and invitro release pattern. Sodium alginate alone or in combination with guargum and the gas forming agent sodium carbonate were dispersed in the purified water to form a homogeneous polymer mixture. Drug and excipients were dissolved in ethanol and dichloromethane 1. All the five formulation displayed sustained release of drug.
Application and advancement of microsphere as controlled. The prepared microspheres were collected and weighed from different formulations. These are gastro retentive drug delivery dosage systems grdds based on noneffervescent approach. Preparation and in vitro characterization of porous. Preparation and characterization of floating drug delivery system of azithromycin shailendra wasnik, poonam parmar, deepika singh and alpana ram. Different quantities of ethyl cellulose and eudragit s 100 were dissolved in dichloromethane by magnetic stirrer.
General method for preparation of floating microspheres floating microspheres containing ofloxacin hydrochloride were prepared by an emulsification solvent evaporation technique soppimath et al. The microspheres were prepared by oilinoil emulsion solvent evaporation technique using ethyl cellulose, methacrylic acid copolymer eudragit rs100, eudragit rspo and eudragit rlpo. Floating microspheres are gastroretentive drug delivery systems based on a noneffervescent approach. Formulation and evaluation of gastroretentive drug delivery system. Hollow microspheres, microballoons or floating microparticles are terms used synonymously for floating microspheres. It can be used for imaging liver metastases and also can be used to distinguish bowel loops from other abdominal structures by forming nano size particles supramagnetic iron oxides. Microspheres microspheres are small spherical particles, with diameter 1. Pdf the main aim of the present investigation is to formulate omeprazole loaded floating microspheres by solvent evaporation technique.
The effect of various formulation variables on the. Research paper preparation and characterization of serratiopeptidase containing microspheres j. Loading into preformed microspheres has an advantage of removing all impurities from microsphere preparation before the drug is incorporated. Formulation and evaluation of captropril microspheres by ionic gelation technique s.
Optimization of methods for the preparation of famotidine floating microspheres singh bandana, kanoujia jovita, pandey manisha, koshy m. These systems have several advantages over conventional multi dose therapy. Formulation and evaluation of floating microsphere containing anti diabetic drug. The layer of buoyant microspheres was pipetted and separated by filtration at 1, 2, 4 and 6 hours. Pdf formulation and evaluation of metformin hcl floating.
The particle size of the microspheres was measured using an optical microscope and the mean particle size was calculated by measuring 100 particles with. Formulation and evaluation of gastroretentive floating. Preparation of floating microspheres floating microspheres were prepared by ionotropic gelation method. To this dispersion, desired polymer in different concentrations was mixed in suitable proportion and stirring is continued. Preparation of floating microspheres the floating microspheres were prepared by solvent evaporation method. Formulation, optimization and evaluation of floating microspheres of captopril. Formulation and invitro evaluation of mucoadhesive. Total ten formulations were prepared by altering the concentration of drug to polymer concentrations. Preparation of polylactidecoglycolide microspheres and.
Pdf the present study involves prepration and evaluation of floating microspheres using boswellic ba as model drug for prolongation of the. Formulation and evaluation of controlled release floating. The floating and the settled portion of microsphere will be recovered separately. Floating microspheres are, in a strict sense, spherical empty particles without a core. The floating microspheres were taken for micromeritic properties such as bulk density, tapped density, carrs index, hausners ratio, angle of repose. Pdf preparation and invitro evaluation of floating. The main aim of the present investigation is to formulate omeprazole loaded floating microspheres by solvent evaporation technique. As a result, drug is localized on the targeted site. Accurately weighed drug and polymers in different ratios are dissolved in the solvents like ethanol and dichloromethane 1. Preparation of floating microspheres of dextromethorphan hbr floating microsphere of dxm hbr was prepared by emulsion solvent evaporation technique. Microspheres are multiparticulate drug delivery systems which are prepared to obtain prolonged or controlled drug delivery to improve bioavailability, stability and to target the drug to specific site at a predetermined rate. Formulation and evaluation of captropril microspheres by. Weight of floating micr ospheres percentage yield x 100. Pdf formulation of floating microspheres of nizatidine.
Floating microspheres have been utilized to obtain prolonged and uniform release of drug in the stomach for development of oncedaily formulations. Role of excipients and polymeric advancements in preparation of. In the present study microspheres containing felodipines were prepared by solvent evaporation method and characterized by optical microscopy and scanning electron microscopy. Ofloxacin 500 mg and polymer 500 mg were weighed accurately. Microspheres was spread over a surface of a usp xxii dissolution apparatus type ii filled with 900ml 0. Recent trends in the development of gastroretentive floating drug delivery system p. Preparation and invitro evaluation of floating microspheres of gabapentin article pdf available january 2011 with 180 reads how we measure reads.
Floating microspheres provide a constant and prolonged therapeutic effect which will reduce dosing frequency. Contents of the powerpoint on formulation and evaluation of microspheres include. Preparation of eudragit e100 microspheres by modified solvent evaporation method vandana singh 1 and amrendra kumar chaudhary2 1translam institute of pharm education and research, meerut, up250001, india 2school of pharmaceutical sciences, shobhit university, meerut, up250110, india. Preparation of microsphere floating microsphere containing metformin hydrochloride was prepared using emulsion solvent diffusion technique19. The measured weight was divided by the total amount of drug and polymers which were used for the preparation of the microspheres to obtained percentage yield. Floating microspheres19, 20 in floating types the bulk density is less than the gastric fluid and so remains buoyant in stomach without. The objective of the present investigation is to formulate multiparticulate gastroretentive dosage form of nizatidine, a h2receptor antagonist widely prescribed in gastric ulcers, duodenal ulcers. Floating microspheres of tolperisone hydrochloride.
The floating microspheres were prepared by emulsion solvent diffusion technique1. Preparation and in vitro characterization of porous carrierbased. During the preparation of microspheres or after the formation of microspheres by incubating. The present study was designed to investigate the effects of different variables on the release profile of ibuprofen microspheres formulated using modified emulsification method. The resulting microspheres were washed with double distilled. The aim of present study involves preparation and characterization of floating microspheres using trimetazidin dihydrochloride as a model drug to increase the residence time in the stomach without contact with the mucosa, floating microspheres were prepared by the capillary extrusion technique using chitosan as polymer and sodium. The mgalldh shell was obtained on the surface of fe 3o.
They are spherical free flowing particles consisting of proteins or synthetic polymers which are biodegradable in nature. Formulation, optimization and evaluation of floating. Floating behavior of floating microsphere12,37 100 mg of the floating microsphere were placed in 0. This organic phase was added slowly to 100 ml of 1. A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. Eight batches of microspheres f1f8 were prepared by applying 2 3 factorial design. Formulation development and evaluation of alginate. Preparation of omeprazole floating microspheres the floating micro spheres were prepared by solvent evaporation method. The effect of various formulation variables on the size and drug release was investigated. The oo single emulsionsolvent evaporation is the best method used for preparation of floating microspheres of gabapentin using ethyl cellulose and cellulose acetate as coating polymeric. Effect of various polymers concentrations on physicochemical.
Preparation and characterization of gastroretentive. The concept of targeted drug delivery is designed for attempting to concentrate the drug in the tissues of interest while reducing the relative concentration of the medication in the remaining tissues. Drug and required polymer, excipients were taken in different ratios as shown in table 1. A controlledrelease system designed to increase residence time in the stomach without contact with the mucosa was achieved through the preparation of floatingmicrospheres by. Preparation and evaluation of floating microspheres of. Floating microspheres are prepared by solvent diffusion and evaporation methods to create the hollow inner core.
References powders and granulates freeflowing powders and granulates are needed for a variety of industrial processes. Hollow microsphere promises to be a potential approach for gastric retention. The pre pared microspheres were evaluated for size, in vitro. The amount of sodium alginate, amount of calcium chloride, and amount of. Gastro retentive floating microspheres are low density systems that have sufficient buoyancy to float over the gastric contents and remain in stomach for prolonged period and slowly released the drug at desired rate. Application and advancement of microsphere as controlled delivery system. The polymer content was a mixture of eudragit rs 100 hydroxypropylmethylcellulose hpmc k4m.
The dried floating microspheres were evaluated for percentage yield %, actul drug content %. The collected microspheres were dried in desiccators. In this the prepared loaded microsphere is analyzed by scanning electronic microscopesemafter palladiumgold coating of the samples on an aluminium strip. Pdf formulation and evaluation of floating microspheres of. Preparation of microsphere the microspheres were prepared using an ionic. The medium is to be agitated with a paddle rotating at 50 rpm for 12 hrs.
The recent developments of fdds including approaches to design singleunit and multipleunit floating systems, mechanism of floating microspheres, methods of preparation of hollow microsphere, list of polymers used in hollow microspheres, characterization of hollow. The drug is released slowly at the desired rate, and the system is found to be floating on gastric content and increases gastric. Floating microspheres were prepared by solvent evaporation oilinwater emulsion technique using. Of microspheres theoretical wgt to be preparedloading 100 x actual amt. Chitosanbased floating microspheres of trimetazidin. Accurately weighed amount of drug was dispersed uniformly in aqueous mucilage of sodium alginate with stirring.
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